Normally I race with AC off. I only use AC in rFactor's MMG F1 mod - as I am not quick enough to avoid the stall if I spin. In any other mod I wouldn't care but in the F1 mod a stall is the end of your race [no starter motor

].
I even found that it helped in GTL to run with AC off. It made me driver properly, watching my braking and lines so I could clutch, de-clutch and shift on acceloration and braking.
On off should be personal preference. I think it is the only option that should be available in Pro modes - as I only got a clutch pedal when I bought my G25 and not everyone has that cash to throw into a wheel.
I don't think this presents an advantage to RWD over FWD - as RWD has an inherent advantage at certain tracks anyway and vice-versa with FWD.
Just my two pennies.